ISQ Single Quadrupole GC-MS

The Thermo Scientific* ISQ* system offers rugged and reliable performance and nonstop productivity.

The Thermo Scientific* ISQ* system offers rugged and reliable performance and nonstop productivity.
The Thermo Scientific ISQ GC-MS features a new source design ideal for continuous high-throughput operation. The vacuum interlock enables source removal without venting the system for nonstop productivity.

– ExtractaBrite* source for analytical robustness and flexibility and vacuum interlock for Full-Source Removal without venting
– Mass range from 1.2-1100 u
– S-Shaped Ion Guide for noise reduction
– Data acquisition rates to match fast chromatography
– Sequential full scan/SIM for qualitative and quantitative analysis in a single injection
– Intelligent dual filament control for reliable operation
– QuanLab* Forms layered application software for easy acquisition, review and reporting of general GC-MS data
– Chemical ionization, including PCI for molecular weight confirmation, NCI for enhanced selectivity and sensitivity, with PPINICI standard for alternating PCI and NCI scans in a single injection
– Choice of gas chromatographs to match GC performance to the analytical needs of your lab
– DEP/DIP direct sample probes for sample analysis without separation
– Range of injection port options, all with available large-volume capabilities for enhanced sensitivity and reduced sample preparation needs
– EnviroLab* Forms and ToxLab* Forms for workflow oriented data acquisition, review and reporting according to specific market needs
– Liquid and headspace autosampler options
– Compatible with additional sample introduction techniques, such as thermal desorption, purge and trap and solid phase microextraction


Standard Mode Electron Ionization (EI), with full scan, SIM, and sequential full scan/SIM
Optional Mode(s) Chemical ionization, including PCI, NCI, PPINICI* and EI/CI Combination
Ion Source Type Thermo Scientific* ExtractaBrite* EI source, with repeller, source lenses, RF lens and dual filaments in all ionization modes, programmable up to 350°C
Source Access Vacuum probe interlock to remove entire source or change ionization modes without venting; Optional combination EI/CI source used for both modes without interchange
Mass Filter Dual-stage mass filter with off-axis ion guide for noise reduction and solid, homogeneous non-coated quadrupole rods
Detector DynaMax XR detection system, with off-axis dynode, discrete dynode electron multiplier and electrometer, linear from 0-68µA
Mass Range 1.2-1100u with unit mass resolution
Acquisition Rate Ability to acquire more than 240 scans/s in SIM; Ability to acquire more than 73 scans/s in full scan when scanning over a range of 125u
Reagent Gas Software-switchable dual reagent gas with digital flow control; Ammonia, methane, isobutane and carbon dioxide preset
Pumping Systems Standard capacity (>60L/s) or extended capacity (300L/s) turbomolecular pump with 3.3 m3/h mechanical pump; Optional oil-free scroll pump
Electron Energy Adjustable from 0 to 150eV
Emission Current Up to 350µA, with improved regulation at low current
Transfer Line Temperature Up to 400°C
Direct Sample Probe System Option Switch to probe in < 3min. with GC undisturbed

Available in two styles: rapid heating filament Direct-Exposure Probe (DEP, capable of flash vaporization or pyrolysis at up to 1000°C) or slower volatilization Direct-Insertion Probe (DIP, capable of accomodation powders and solid samples in a quartz or aluminum crucible)

NoVent Microfluidics Option for the TRACE 1300/1310 For easier column replacement without venting the system; Consists of a low-volume, highly inert Silflow* technology with finger-tight connectors
Data System Software and Options Thermo Scientific Xcalibur* Data system, common platform for all Thermo Scientific MS systems

Thermo Scientific Dionex* Chromeleon™ Simply Intelligent Enterprise CDS for chromatographers using MS

Thermo Scientific TraceFinde*™ Software for routine GC-MS quantification

TraceFinder Software for Environmental and Food Safety

TraceFinder Software for Clinical Research

TraceFinder Software for Forensic Technology

Instrument control and data connection via Ethernet

Computer supplied with instrument equipped with three Ethernet (8P8C RJ-45) ports

Commercial mass spectral library options, including:–NIST and Wiley libraries– Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and theirMetabolites (Maurer-Pfleger-Weber library)

Standard Installation Specifications†
Electron Ionization Signal-to-Noise 1µL of 1pg/µL octafluoronaphthalene (OFN) will produce the following minimum signal to noise for m/z 272 when scanning from 50 to 300u:1500:1using helium as carrier gas: 100:1 using hydrogen as carrier gas
Positive Chemical Ionization Signal-to-Noise 1µL of 100pg/µL benzophenone will produce the following minimum signal to noise for m/z 183 when scanning from 80 to 230u using methane reagent gas: 300:1 using helium as carrier gas: 300:1 using hydrogen as carrier gas
Negative Chemical Ionization Signal-to-Noise 2µL of 100fg/µL of OFN will produce the following minimum signal to noise for m/z 272 when scanning from 50 to 300u using methane reagent gas:600:1 using helium as carrier gas: 600:1 using hydrogen as carrier gas
Typical Specification
Typical Specification In EI SIM mode, with He carrier gas and either the AI/AS 1310 or TriPlus RSH autosampler (required and configured for liquid injections), eight sequential fg OFN splitless injections monitored for m/z 272 produced the following instrument detection limit (IDL), calculated from the chromatographic peak area with 99% confidence interval: IDL <=10fg
System Dimensions/Weights Total width of the connected GC/MS system is 80cm (31 in). Allow 16 cm (6 in) of clearance behind the instrument (32cm if using autosampler). Additional space should be allotted for data system and printer
Mass Spectrometer (height x width x depth) 44 x 33 x 63cm (17.5 x 13 x 24.5 in.)

Weight: 43kg (94 lb.)

TRACE 1300/1310 GC 45 x 44 x 60/67cm (18 x 17 x 24/26 in.)

Weight: 35kg (77 lb.)

†Helium standard specifications are performed using a 15m x 0.25mm ID x 0.25µm System Qualification Column (SQC). Hydrogen standard specifications are performed using a 30m × 0.25mm ID × 0.25µm System Qualification Column (SQC). The installation specifications are performed with either He or H2 but not both.