TSQ Quantum XLS

TSQ Quantum XLS Triple Quadrupole GC-MS/MS

The Thermo Scientific* TSQ Quantum XLS delivers the highest sensitivity with femtogram-range limits of detection and unrivaled performance in GC-MS/MS structure selective detection for multi-component target compound quantitation.

TSQ Quantum XLS Triple Quadrupole GC-MS/MS

The Thermo Scientific* TSQ Quantum XLS delivers the highest sensitivity with femtogram-range limits of detection and unrivaled performance in GC-MS/MS structure selective detection for multi-component target compound quantitation.

The TSQ Quantum XLS improves laboratory efficiency and throughput. The robust design of the system offers greater flexibility, high-speed data acquisition and more sample runs, further increasing laboratory productivity.

– DuraBrite* IRIS source technology delivers class-leading sensitivity and robustness

– Highest selectivity for complex matrix samples with enhanced mass resolution (H-SRM)

– Ability to analyze a virtually unlimited number of target compounds in a single GC run with 1ms dwell times

– EZ-method setup from Excel tables with timed-SRM at compound retention times

– Simultaneous quantitation and confirmation with QED-MS/MS

– Vacuum interlock for ion volume removal or changing of ionization modes without venting

– PPINICI* Pulsed Positive Ion Negative Ion Chemical Ionization for sample screening

– Convertible between GC/MS and LC/MS

– Mass range from 1.2 to 3000u

– 90° collision cell for zero cross talk and low noise levels

– Precision hyperbolic quadrupole technology for increased selectivity and H-SRM capabilities

– Structure Selective Detection for confident quantitation in matrix

– Anlaytical flexibility with fast switching from EI to CI modes

– Convertible between gas and liquid chromatography separation techniques

– 21 CFR Part 11 enabled software for regulatory compliance

– QuanLab* Forms layered application software for easy acquisition, review and reporting of GC-MS data

Specifications

Triple Quadrupole Mass Analyzer
High precision Thermo Scientific HyperQuad mass analyzers Q1 and Q3 provide superior and unique combination of higher mass resolution and increased sensitivity
Highly selective Selected Reaction Monitoring (H-SRM) with increased mass resolution at 0.4 Da peak width (FWHM)
Highly selective Selected Ion Monitoring (H-SIM) mode
Mass resolution adjustable from 0.4 Da to 5.0 Da peak width (FWHM) (Q1)
Variable peak width selection in all scan modes
MRM Multi-compound detection with up to 3000 retention timed SRM transitions in one analytical GC run
Minimum dwell time of 1ms for SRM and H-SRM operation
Fast MRM scan speed of more than 300 SRM/s
90° high-efficiency noise-cutting collision cell
Crosstalk free CID operation
CID gas pressure programmable through the software
Collision gases argon (specified) or nitrogen
Mass range of m/z 10-3000
Full mass scan rate of 5000 Da/s
Vacuum System
  • Unique close-coupled triple inlet turbo molecular pumping 270L/s
  • Two stages of pumping provide optimal vacuum throughout GC-MS/MS analyzer

Single mechanical pump 30L/min, floor standing

Detection System
  • Off-axis ion detection system
  • Fast switching (< 25ms) post-acceleration conversion dynode with ±10kV applied voltage
  • Off-axis continuous dynode electron multiplier with increased dynamic range > 10 E6 (electronic)
  • System integrated electron multiplier eliminates field emission and microphonic noise
  • Centroid or profile data acquisition modes

PPINICI mode to acquire positive ion CI and negative ion CI spectra in alternating scans

Scan Modes
  • Highly sensitive full-scan MS in Q1 or Q3
  • Selected Reaction Monitoring (SRM) for demanding quantitative assays
  • Timed-SRM EZ method detects eluting compounds at the specific retention time—no need to define segment breaks
  • Highly Selective Reaction Monitoring (H-SRM) for optimal selectivity
  • Selected Ion Monitoring (SIM) in Q1 or Q3
  • Highly selective Selected Ion Monitoring (H-SIM) mode
  • Product Ion Scan
  • Precursor Ion Scan

Neutral Loss Scan

Advanced Data-Dependent Experiments
  • Available from all scan functions
  • Dynamic Exclusion* allows acquisition of MS/MS spectra from lower intensity ion species
  • Polarity switching capabilities
  • AutoSIM
  • Quantitation-enhanced Data-dependent MS/MS (QED-MS/MS) for simultaneous compound confirmation and quantitation
  • Reverse Energy Ramp MS/MS spectra (RER) gives information-rich MS/MS spectra from a range of collisio energies for solid compound identification e.g. using spectral library comparison
System Dimensions
69 x  56 x  79cm (27 x 22 x 31 in.)
Weight
118 kg (260 lb.)